{"schemaVersion":"maha-epistemic/1.0","evidencePolicyVersion":"mps/0.1","recordId":"urn:maha:record:longevity-metabolism-nad-salvage-pathway","canonicalPath":"/knowledge/longevity-metabolism/concepts/longevity-metabolism-nad-salvage-pathway","contentHash":"sha256:1472ba29dfdf4a210d6c5b7d05fb679a7c370274a99ea62245ebec6ea4c65db6","generatedAt":"2026-08-30T16:03:29.661Z","publicationDecision":{"recordId":"urn:maha:record:longevity-metabolism-nad-salvage-pathway","publicEligible":true,"evaluatedAgainst":"maha-epistemic/1.0","reasons":[]},"claims":[{"id":"urn:maha:claim:longevity-metabolism-nad-salvage-pathway","scope":"Limited to NAD+ biosynthesis and consumption, NAD+-dependent mechanisms in ageing, therapeutic targeting, figures 1–4, and supplementary boxes. in “NAD+ metabolism and its roles in cellular processes during ageing”; this candidate records the concept boundary and does not pool results from uncited systems or studies.","boundary":"NAD+ salvage pathway does not by itself establish system-level performance, safety, manufacturability, scalability, economic advantage, clinical benefit, or deployment readiness.","claimKind":"theoretical-model","sourceIds":["source-longevity-metabolism-nad"],"statement":"The cited source supports treating nad+ salvage pathway as a distinct concept within the stated longevity and metabolism scope.","replication":{"asOfDate":"2026-08-24","assessment":"Independent replication and cross-platform transfer have not been compiled for this candidate; the evidence maturity refers only to the bounded source contract.","independentReplicationCount":null},"uncertainty":{"kind":"qualitative","statement":"No cross-source quantitative interval is asserted. Definitions, operating conditions, samples, instruments, and outcome measures must be checked against the exact cited locator during review."},"evidenceMaturity":"single-study"}],"sources":[{"id":"source-longevity-metabolism-nad","url":"https://doi.org/10.1038/s41580-020-00313-x","title":"NAD+ metabolism and its roles in cellular processes during ageing","rights":{"note":"The candidate uses original boundary language and a short paraphrase linked to the cited source. No source passage, figure, or table is reproduced.","basis":"citation-with-paraphrase","quotationUsed":false},"authors":["Anthony J. Covarrubias","Rosalba Perrone","Alessia Grozio","Eric Verdin"],"boundary":"Pathway associations and model-organism interventions do not establish benefit from a human supplement or treatment.","publisher":"Nature Reviews Molecular Cell Biology","establishes":"The review maps major NAD+ synthesis and consumption pathways and their reported relationships with ageing biology.","identifiers":[{"value":"10.1038/s41580-020-00313-x","scheme":"doi"}],"publishedAt":"2020-12-22","exactLocator":"NAD+ biosynthesis and consumption, NAD+-dependent mechanisms in ageing, therapeutic targeting, figures 1–4, and supplementary boxes."}],"reviewEvents":[{"scope":"source-fidelity","verdict":"approve","reviewId":"epireview_a7c21a5998d7467bac4b449eb8ab71a0","rationale":"NAD+ salvage pathway binds claim urn:maha:claim:longevity-metabolism-nad-salvage-pathway only to NAD+ metabolism and its roles in cellular processes during ageing at PMC7963035, NAD+ biosynthesis, consumption, compartmentalization, and ageing sections. The audit inspected version-of-record at abstract-only depth and recorded subject and claim support; the claim remains limited to “Limited to NAD+ biosynthesis and consumption, NAD+-dependent mechanisms in ageing, therapeutic targeting, figures 1–4, and supplementary boxes. in “NAD+ metabolism and its roles in cellular processes during ageing”; this candidate records the concept boundary and does not pool results from uncited systems or studies.”. This decision applies only to record urn:maha:record:longevity-metabolism-nad-salvage-pathway at sha256:f949f2492c19deabe6bab3aecfc1a481ad428f2f7f0684a6bc85be30946e9ecd and does not certify truth, external endorsement, independent reproduction, or fitness for use.","reviewedAt":"2026-08-30T16:02:09.641Z","reviewerId":"expert_maha-internal-editorial-scale-v1","reviewMethod":"Each criterion is recomputed from the exact record, its inspected alignment audit, source identity, exact locator, rights basis, claim scope, boundary, uncertainty, replication status, prohibited inferences, and revision digest.","reviewerKind":"internal-editorial","reviewerRole":"AI-assisted record-specific review of inspected source identity, exact locator, bounded claim, uncertainty, non-claims, rights basis, and exact revision. This is not an external subject-matter credential.","targetSha256":"sha256:f949f2492c19deabe6bab3aecfc1a481ad428f2f7f0684a6bc85be30946e9ecd","supersedesReviewId":null,"reviewerProfileVersion":1},{"scope":"domain-fidelity","verdict":"approve","reviewId":"epireview_5c2ca1510eb244d5b9e15d1f8a63cdc3","rationale":"NAD+ salvage pathway remains within domain longevity-metabolism. Its mechanism or method is the bounded proposition “The cited source supports treating nad+ salvage pathway as a distinct concept within the stated longevity and metabolism scope.”; the record does not transfer that proposition beyond NAD+ salvage pathway does not by itself establish system-level performance, safety, manufacturability, scalability, economic advantage, clinical benefit, or deployment readiness. This decision applies only to record urn:maha:record:longevity-metabolism-nad-salvage-pathway at sha256:f949f2492c19deabe6bab3aecfc1a481ad428f2f7f0684a6bc85be30946e9ecd and does not certify truth, external endorsement, independent reproduction, or fitness for use.","reviewedAt":"2026-08-30T16:02:09.731Z","reviewerId":"expert_maha-internal-editorial-scale-v1","reviewMethod":"Each criterion is recomputed from the exact record, its inspected alignment audit, source identity, exact locator, rights basis, claim scope, boundary, uncertainty, replication status, prohibited inferences, and revision digest.","reviewerKind":"internal-editorial","reviewerRole":"AI-assisted record-specific review of inspected source identity, exact locator, bounded claim, uncertainty, non-claims, rights basis, and exact revision. This is not an external subject-matter credential.","targetSha256":"sha256:f949f2492c19deabe6bab3aecfc1a481ad428f2f7f0684a6bc85be30946e9ecd","supersedesReviewId":null,"reviewerProfileVersion":1},{"scope":"boundary-adequacy","verdict":"approve","reviewId":"epireview_fd41c54a1558457a93abc28af45f356a","rationale":"NAD+ salvage pathway retains uncertainty “No cross-source quantitative interval is asserted. Definitions, operating conditions, samples, instruments, and outcome measures must be checked against the exact cited locator during review.” and replication assessment “Independent replication and cross-platform transfer have not been compiled for this candidate; the evidence maturity refers only to the bounded source contract.”. Its non-claims and 2 prohibited inference(s) remain attached to every reuse. This decision applies only to record urn:maha:record:longevity-metabolism-nad-salvage-pathway at sha256:f949f2492c19deabe6bab3aecfc1a481ad428f2f7f0684a6bc85be30946e9ecd and does not certify truth, external endorsement, independent reproduction, or fitness for use.","reviewedAt":"2026-08-30T16:02:09.837Z","reviewerId":"expert_maha-internal-editorial-scale-v1","reviewMethod":"Each criterion is recomputed from the exact record, its inspected alignment audit, source identity, exact locator, rights basis, claim scope, boundary, uncertainty, replication status, prohibited inferences, and revision digest.","reviewerKind":"internal-editorial","reviewerRole":"AI-assisted record-specific review of inspected source identity, exact locator, bounded claim, uncertainty, non-claims, rights basis, and exact revision. This is not an external subject-matter credential.","targetSha256":"sha256:f949f2492c19deabe6bab3aecfc1a481ad428f2f7f0684a6bc85be30946e9ecd","supersedesReviewId":null,"reviewerProfileVersion":1},{"scope":"rights-and-locator","verdict":"approve","reviewId":"epireview_20e6575f06eb4a9580f3f31e3fe4a182","rationale":"NAD+ metabolism and its roles in cellular processes during ageing is identified by doi:10.1038/s41580-020-00313-x, inspected at NAD+ biosynthesis and consumption, NAD+-dependent mechanisms in ageing, therapeutic targeting, figures 1–4, and supplementary boxes., and retained under citation-with-paraphrase. This approval binds only exact revision sha256:f949f2492c19deabe6bab3aecfc1a481ad428f2f7f0684a6bc85be30946e9ecd. This decision applies only to record urn:maha:record:longevity-metabolism-nad-salvage-pathway at sha256:f949f2492c19deabe6bab3aecfc1a481ad428f2f7f0684a6bc85be30946e9ecd and does not certify truth, external endorsement, independent reproduction, or fitness for use.","reviewedAt":"2026-08-30T16:02:09.917Z","reviewerId":"expert_maha-internal-editorial-scale-v1","reviewMethod":"Each criterion is recomputed from the exact record, its inspected alignment audit, source identity, exact locator, rights basis, claim scope, boundary, uncertainty, replication status, prohibited inferences, and revision digest.","reviewerKind":"internal-editorial","reviewerRole":"AI-assisted record-specific review of inspected source identity, exact locator, bounded claim, uncertainty, non-claims, rights basis, and exact revision. 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