{"schemaVersion":"maha-epistemic/1.0","evidencePolicyVersion":"mps/0.1","recordId":"urn:maha:record:longevity-metabolism-senolytic-selectivity","canonicalPath":"/knowledge/longevity-metabolism/methods/longevity-metabolism-senolytic-selectivity","contentHash":"sha256:80ea1c924dc05f40671f629b29a21ab73f62c676c827f03d33cd66228058914a","generatedAt":"2026-08-30T16:03:28.170Z","publicationDecision":{"recordId":"urn:maha:record:longevity-metabolism-senolytic-selectivity","publicEligible":true,"evaluatedAgainst":"maha-epistemic/1.0","reasons":[]},"claims":[{"id":"urn:maha:claim:longevity-metabolism-senolytic-selectivity","scope":"Limited to Senescent-cell survival pathways, compound screening, cell assays, and mouse experiments. in “The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs”; this candidate records the concept boundary and does not pool results from uncited systems or studies.","boundary":"Senolytic selectivity does not by itself establish system-level performance, safety, manufacturability, scalability, economic advantage, clinical benefit, or deployment readiness.","claimKind":"theoretical-model","sourceIds":["source-longevity-metabolism-senolytics"],"statement":"The cited source supports treating senolytic selectivity as a distinct method within the stated longevity and metabolism scope.","replication":{"asOfDate":"2026-08-24","assessment":"Independent replication and cross-platform transfer have not been compiled for this candidate; the evidence maturity refers only to the bounded source contract.","independentReplicationCount":null},"uncertainty":{"kind":"qualitative","statement":"No cross-source quantitative interval is asserted. Definitions, operating conditions, samples, instruments, and outcome measures must be checked against the exact cited locator during review."},"evidenceMaturity":"single-study"}],"sources":[{"id":"source-longevity-metabolism-senolytics","url":"https://doi.org/10.1111/acel.12344","title":"The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs","rights":{"note":"The candidate uses original boundary language and a short paraphrase linked to the cited source. No source passage, figure, or table is reproduced.","basis":"citation-with-paraphrase","quotationUsed":false},"authors":["Yi Zhu","Tamara Tchkonia","Tamar Pirtskhalava","et al."],"boundary":"Preclinical selectivity and clearance results do not establish human safety, dosing, efficacy, or lifespan extension.","publisher":"Aging Cell","establishes":"The study identifies candidate senolytic vulnerabilities and reports cell- and animal-model experiments for specified compounds.","identifiers":[{"value":"10.1111/acel.12344","scheme":"doi"}],"publishedAt":"2015-01-01","exactLocator":"Senescent-cell survival pathways, compound screening, cell assays, and mouse experiments."}],"reviewEvents":[{"scope":"source-fidelity","verdict":"approve","reviewId":"epireview_c1f7206e9bf046c1a0026639ee8666c3","rationale":"Senolytic selectivity binds claim urn:maha:claim:longevity-metabolism-senolytic-selectivity only to The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs at Aging Cell 14(4) 644-658 article text: survival pathways, compound screening, cell assays and mouse experiments. The audit inspected version-of-record at abstract-only depth and recorded subject and claim support; the claim remains limited to “Limited to Senescent-cell survival pathways, compound screening, cell assays, and mouse experiments. in “The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs”; this candidate records the concept boundary and does not pool results from uncited systems or studies.”. This decision applies only to record urn:maha:record:longevity-metabolism-senolytic-selectivity at sha256:97051b2ab5681c95d7564cccc58a2982d124f07d562274041fdbe41a500e876a and does not certify truth, external endorsement, independent reproduction, or fitness for use.","reviewedAt":"2026-08-30T16:02:09.348Z","reviewerId":"expert_maha-internal-editorial-scale-v1","reviewMethod":"Each criterion is recomputed from the exact record, its inspected alignment audit, source identity, exact locator, rights basis, claim scope, boundary, uncertainty, replication status, prohibited inferences, and revision digest.","reviewerKind":"internal-editorial","reviewerRole":"AI-assisted record-specific review of inspected source identity, exact locator, bounded claim, uncertainty, non-claims, rights basis, and exact revision. This is not an external subject-matter credential.","targetSha256":"sha256:97051b2ab5681c95d7564cccc58a2982d124f07d562274041fdbe41a500e876a","supersedesReviewId":null,"reviewerProfileVersion":1},{"scope":"domain-fidelity","verdict":"approve","reviewId":"epireview_6165c25ea8c845c084dbfc6f4a635550","rationale":"Senolytic selectivity remains within domain longevity-metabolism. Its mechanism or method is the bounded proposition “The cited source supports treating senolytic selectivity as a distinct method within the stated longevity and metabolism scope.”; the record does not transfer that proposition beyond Senolytic selectivity does not by itself establish system-level performance, safety, manufacturability, scalability, economic advantage, clinical benefit, or deployment readiness. This decision applies only to record urn:maha:record:longevity-metabolism-senolytic-selectivity at sha256:97051b2ab5681c95d7564cccc58a2982d124f07d562274041fdbe41a500e876a and does not certify truth, external endorsement, independent reproduction, or fitness for use.","reviewedAt":"2026-08-30T16:02:09.432Z","reviewerId":"expert_maha-internal-editorial-scale-v1","reviewMethod":"Each criterion is recomputed from the exact record, its inspected alignment audit, source identity, exact locator, rights basis, claim scope, boundary, uncertainty, replication status, prohibited inferences, and revision digest.","reviewerKind":"internal-editorial","reviewerRole":"AI-assisted record-specific review of inspected source identity, exact locator, bounded claim, uncertainty, non-claims, rights basis, and exact revision. This is not an external subject-matter credential.","targetSha256":"sha256:97051b2ab5681c95d7564cccc58a2982d124f07d562274041fdbe41a500e876a","supersedesReviewId":null,"reviewerProfileVersion":1},{"scope":"boundary-adequacy","verdict":"approve","reviewId":"epireview_0bd93cf4e62d44d4adb81a3b28f186e3","rationale":"Senolytic selectivity retains uncertainty “No cross-source quantitative interval is asserted. Definitions, operating conditions, samples, instruments, and outcome measures must be checked against the exact cited locator during review.” and replication assessment “Independent replication and cross-platform transfer have not been compiled for this candidate; the evidence maturity refers only to the bounded source contract.”. Its non-claims and 2 prohibited inference(s) remain attached to every reuse. This decision applies only to record urn:maha:record:longevity-metabolism-senolytic-selectivity at sha256:97051b2ab5681c95d7564cccc58a2982d124f07d562274041fdbe41a500e876a and does not certify truth, external endorsement, independent reproduction, or fitness for use.","reviewedAt":"2026-08-30T16:02:09.499Z","reviewerId":"expert_maha-internal-editorial-scale-v1","reviewMethod":"Each criterion is recomputed from the exact record, its inspected alignment audit, source identity, exact locator, rights basis, claim scope, boundary, uncertainty, replication status, prohibited inferences, and revision digest.","reviewerKind":"internal-editorial","reviewerRole":"AI-assisted record-specific review of inspected source identity, exact locator, bounded claim, uncertainty, non-claims, rights basis, and exact revision. This is not an external subject-matter credential.","targetSha256":"sha256:97051b2ab5681c95d7564cccc58a2982d124f07d562274041fdbe41a500e876a","supersedesReviewId":null,"reviewerProfileVersion":1},{"scope":"rights-and-locator","verdict":"approve","reviewId":"epireview_8d5d1c5424124cdf86f2d30e78a959ac","rationale":"The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs is identified by doi:10.1111/acel.12344, inspected at Senescent-cell survival pathways, compound screening, cell assays, and mouse experiments., and retained under citation-with-paraphrase. This approval binds only exact revision sha256:97051b2ab5681c95d7564cccc58a2982d124f07d562274041fdbe41a500e876a. This decision applies only to record urn:maha:record:longevity-metabolism-senolytic-selectivity at sha256:97051b2ab5681c95d7564cccc58a2982d124f07d562274041fdbe41a500e876a and does not certify truth, external endorsement, independent reproduction, or fitness for use.","reviewedAt":"2026-08-30T16:02:09.578Z","reviewerId":"expert_maha-internal-editorial-scale-v1","reviewMethod":"Each criterion is recomputed from the exact record, its inspected alignment audit, source identity, exact locator, rights basis, claim scope, boundary, uncertainty, replication status, prohibited inferences, and revision digest.","reviewerKind":"internal-editorial","reviewerRole":"AI-assisted record-specific review of inspected source identity, exact locator, bounded claim, uncertainty, non-claims, rights basis, and exact revision. This is not an external subject-matter credential.","targetSha256":"sha256:97051b2ab5681c95d7564cccc58a2982d124f07d562274041fdbe41a500e876a","supersedesReviewId":null,"reviewerProfileVersion":1}]}