{"schemaVersion":"maha-epistemic/1.0","evidencePolicyVersion":"mps/0.1","recordId":"urn:maha:record:genome-editor-delivery-systems","canonicalPath":"/knowledge/synthetic-biology/methods/genome-editor-delivery-systems","contentHash":"sha256:142ae4fbdceaeeacd9dccb782d8e7f35a59cae6ac3a6153c4ab4e8d781137bbf","generatedAt":"2026-08-30T16:02:44.791Z","publicationDecision":{"recordId":"urn:maha:record:genome-editor-delivery-systems","publicEligible":true,"evaluatedAgainst":"maha-epistemic/1.0","reasons":[]},"claims":[{"id":"urn:maha:claim:genome-editor-delivery-systems","scope":"The constructs, biological systems, protocols, assays, datasets, and comparisons reported in CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis.","boundary":"One liver-targeted formulation does not establish delivery to other tissues, repeat dosing, long-term safety, or a general delivery platform.","claimKind":"empirical-claim","sourceIds":["source-gillmore-in-vivo-2021"],"statement":"The cited phase 1 study reports systemic lipid-nanoparticle delivery of Cas9 mRNA and guide RNA to hepatocytes under a named investigational protocol.","replication":{"asOfDate":"2026-08-24","assessment":"This candidate records one bounded source package. 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The audit inspected version-of-record at declared inspected location depth and recorded subject and claim support; the claim remains limited to “The constructs, biological systems, protocols, assays, datasets, and comparisons reported in CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis.”. This decision applies only to record urn:maha:record:genome-editor-delivery-systems at sha256:96fcae910ef78135fbf36ae41f11fd0fbc6d6ccce6ea326509405f1bb4420fc8 and does not certify truth, external endorsement, independent reproduction, or fitness for use.","reviewedAt":"2026-08-30T16:02:00.681Z","reviewerId":"expert_maha-internal-editorial-scale-v1","reviewMethod":"Each criterion is recomputed from the exact record, its inspected alignment audit, source identity, exact locator, rights basis, claim scope, boundary, uncertainty, replication status, prohibited inferences, and revision digest.","reviewerKind":"internal-editorial","reviewerRole":"AI-assisted record-specific review of inspected source identity, exact locator, bounded claim, uncertainty, non-claims, rights basis, and exact revision. 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This decision applies only to record urn:maha:record:genome-editor-delivery-systems at sha256:96fcae910ef78135fbf36ae41f11fd0fbc6d6ccce6ea326509405f1bb4420fc8 and does not certify truth, external endorsement, independent reproduction, or fitness for use.","reviewedAt":"2026-08-30T16:02:00.791Z","reviewerId":"expert_maha-internal-editorial-scale-v1","reviewMethod":"Each criterion is recomputed from the exact record, its inspected alignment audit, source identity, exact locator, rights basis, claim scope, boundary, uncertainty, replication status, prohibited inferences, and revision digest.","reviewerKind":"internal-editorial","reviewerRole":"AI-assisted record-specific review of inspected source identity, exact locator, bounded claim, uncertainty, non-claims, rights basis, and exact revision. 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This decision applies only to record urn:maha:record:genome-editor-delivery-systems at sha256:96fcae910ef78135fbf36ae41f11fd0fbc6d6ccce6ea326509405f1bb4420fc8 and does not certify truth, external endorsement, independent reproduction, or fitness for use.","reviewedAt":"2026-08-30T16:02:00.924Z","reviewerId":"expert_maha-internal-editorial-scale-v1","reviewMethod":"Each criterion is recomputed from the exact record, its inspected alignment audit, source identity, exact locator, rights basis, claim scope, boundary, uncertainty, replication status, prohibited inferences, and revision digest.","reviewerKind":"internal-editorial","reviewerRole":"AI-assisted record-specific review of inspected source identity, exact locator, bounded claim, uncertainty, non-claims, rights basis, and exact revision. 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This decision applies only to record urn:maha:record:genome-editor-delivery-systems at sha256:96fcae910ef78135fbf36ae41f11fd0fbc6d6ccce6ea326509405f1bb4420fc8 and does not certify truth, external endorsement, independent reproduction, or fitness for use.","reviewedAt":"2026-08-30T16:02:01.005Z","reviewerId":"expert_maha-internal-editorial-scale-v1","reviewMethod":"Each criterion is recomputed from the exact record, its inspected alignment audit, source identity, exact locator, rights basis, claim scope, boundary, uncertainty, replication status, prohibited inferences, and revision digest.","reviewerKind":"internal-editorial","reviewerRole":"AI-assisted record-specific review of inspected source identity, exact locator, bounded claim, uncertainty, non-claims, rights basis, and exact revision. This is not an external subject-matter credential.","targetSha256":"sha256:96fcae910ef78135fbf36ae41f11fd0fbc6d6ccce6ea326509405f1bb4420fc8","supersedesReviewId":null,"reviewerProfileVersion":1}]}