Source evidence reference

De novo design of protein structure and function with RFdiffusion

Joseph L. Watson, David Juergens, Nathaniel R. Bennett, et al. · Nature · 2023-07-11

Identifier 10.1038/s41586-023-06415-8 · version inspected: version of record as cited

This page is a projection of Maha canonical record releases about one source. It is not a separately certified source assessment, not an independent review, and not a replication. Every finding below is carried from a released record and disappears from this page when that record is withdrawn.

What the source investigates

What De novo design of protein structure and function with RFdiffusion investigates, and what Maha records released against it establish.

Evidence type: section or full-text inspection of the cited source

Sections inspected

• Abstract; unconditional generation, motif scaffolding, binder design, Methods, and Extended Data.

Access and rights basis: citation-with-paraphrase

Findings carried from released records

• The cited source supports treating protein backbone diffusion as a distinct concept within the stated biomolecular engineering scope.

  Released record · Abstract; unconditional generation, motif scaffolding, binder design, Methods, and Extended Data.

• The cited source supports treating unconditional protein generation as a distinct mechanism within the stated biomolecular engineering scope.

  Released record · Abstract; unconditional generation, motif scaffolding, binder design, Methods, and Extended Data.

• The cited source supports treating motif scaffolding as a distinct method within the stated biomolecular engineering scope.

  Released record · Abstract; unconditional generation, motif scaffolding, binder design, Methods, and Extended Data.

• The cited source supports treating de novo binder design as a distinct measurement within the stated biomolecular engineering scope.

  Released record · Abstract; unconditional generation, motif scaffolding, binder design, Methods, and Extended Data.

• The cited source supports treating structure prediction filtering as a distinct comparison within the stated biomolecular engineering scope.

  Released record · Abstract; unconditional generation, motif scaffolding, binder design, Methods, and Extended Data.

What this source does not establish

• Independent replication of any result reported by the source.
• Any claim from a Maha record that is not currently released.
• Endorsement, peer review or expert consensus by Maha.

Limitations

• A projection of released record claims. It adds no finding of its own.
• Inspection reached the locators listed above and no further.

Typed bridges

• mechanistic-dependency: undefined
• mechanistic-dependency: undefined
• mechanistic-dependency: undefined
• mechanistic-dependency: undefined

Related released records

• /knowledge/biomolecular-engineering/concepts/biomolecular-engineering-protein-backbone-diffusion
• /knowledge/biomolecular-engineering/mechanisms/biomolecular-engineering-unconditional-protein-generation
• /knowledge/biomolecular-engineering/methods/biomolecular-engineering-motif-scaffolding
• /knowledge/biomolecular-engineering/measurements/biomolecular-engineering-de-novo-binder-design
• /knowledge/biomolecular-engineering/comparisons/biomolecular-engineering-structure-prediction-filtering

Provenance digest sha256:253046431095b8c649f3d40ea3173984c358311e94ec1305be86382b4e77e779 · route /knowledge/sources/10-1038-s41586-023-06415-8