Bounded definition
An evolved deaminase–Cas architecture that can install selected A-to-G outcomes without programmed DNA cleavage.
What the cited work establishes
The study evolves and characterizes adenine base editors that install targeted A-to-G outcomes in specified bacterial and human-cell experiments.
The constructs, biological systems, protocols, assays, datasets, and comparisons reported in Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage.
Claims: urn:maha:claim:adenine-base-editing
What remains a separate question
The source does not establish universal specificity, delivery, tissue performance, safety, or clinical benefit.
Reported performance does not transfer automatically to other editors, guides, loci, cells, delivery systems, organisms, or clinical settings.
Connected domain graph
Typed dependencies preserve publication state.
Only independently canonical records receive public links and relation statements. Draft graph topology remains private.
Directed-evolution workflows
outbound connection · method
The adenine deaminase activity was created through directed protein evolution.
Editing efficiency and byproduct measurement
outbound connection · measurement
Targeted products and byproducts require experiment-level measurement.
Directed-evolution workflows
inbound connection · method
Directed evolution supplied the deaminase activity used in the cited adenine base-editor lineage.
Claim ledger
Every proposition keeps its own evidence state.
The cited study evolves adenine base editors and characterizes targeted A-to-G editing in specified experimental systems.
- Scope
- The constructs, biological systems, protocols, assays, datasets, and comparisons reported in Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage.
- Boundary
- The source does not establish universal specificity, delivery, tissue performance, safety, or clinical benefit.
- Uncertainty
- There is no universal effect estimate for this method; numerical results remain attached to the source experiment, biological system, assay, and analysis choices.
- Replication
- This candidate records one bounded source package. Independent replications and contradictory results must be compiled separately before evidence maturity is upgraded.
Primary sources
Citation, locator, rights, and boundary travel together.
Source 1 · Nature
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
Nicole M. Gaudelli, Alexis C. Komor, Holly A. Rees, Michael S. Packer, et al.
- Exact locator
- Abstract; Figures 1–5; Methods; Extended Data; Supplementary Information.
- Establishes
- The study evolves and characterizes adenine base editors that install targeted A-to-G outcomes in specified bacterial and human-cell experiments.
- Boundary
- Reported performance does not transfer automatically to other editors, guides, loci, cells, delivery systems, organisms, or clinical settings.
- Rights basis
- citation with paraphrase · Maha paraphrases the source-level result and links to the version of record; no article passage is reproduced.
- Declared interests
- The article declares patent applications and company interests involving base-editing technologies.